Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN4172 |
Guajadial B
|
Topoisomerase | DNA Damage/DNA Repair |
Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines, it is the most effective having an IC50 value of 150 nM toward A549 cells. |